101 = 5! – 4! + 3! – 2! + 1!
101 is the sum of five consecutive primes: 13 + 17 + 19 + 23 + 29 = 101.
101 is the smallest odd prime that can be represented as the sum of a square and its reverse: 100 + 001 = 101.
A googol (10100) contains 101 digits.
John Nash's Princeton office number in the movie A Beautiful Mind was 101.
Source: Prime Curios!